Authors: James Bauer

In

By Adobe Reader

His Secret Obsession PDF is a collection of 213 pages include the secret relationship that will help you make a man fall deep in love with you, and teaches you how to make a man obsess over you by triggering his hero instinct. The His Secret Obsession PDF is created by James Bauer.

Authors: Drew Sgoutas

In

By Adobe Reader

The Smoothie Diet PDF is an online program that will help you lose 5 lbs to 10 lbs in just 21 days naturally. The Smoothie Diet PDF is created by Drew Sgoutas. If you're looking for a transform the body shape and lose weight 5-10 lbs or you want to get rid of 40 lbs or more in just 3 weeks then you should download the PDF of The Smoothie Diet.

Authors: James Anderson

In

By James Anderson

Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity (DIO) or leptin deficiency (Lepob/ob). Small molecule inhibition of the gut microbial enzyme choline TMA-lyase (CutC) does not reduce food intake but is instead associated with alterations in the gut microbiome, improvement in glucose tolerance, and enhanced energy expenditure. We also show that gut microbial CutC inhibition is associated with reorganization of host circadian control of both phosphatidylcholine and energy metabolism. This study underscores the relationship between microbe and host metabolism and provides evidence that gut microbe-derived trimethylamine (TMA) is a key regulator of the host circadian clock. This work also demonstrates that gut microbe-targeted enzyme inhibitors have potential as anti-obesity therapeutics.